Liquid Chromatography in Pharmaceutical Analysis VII: Determination of Dantrolene Sodium in Biological Fluids

Dantrolene sodium can be determined in plasma and urine samples by high-pressure liquid chromatography without interference from its two major metabolites, the hydroxy and acetamido compounds. The minimum detectability of the drug using this procedure is 8ng. The complete assay including extraction,...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1977-05, Vol.66 (5), p.751-753
Hauptverfasser:	Saxena, S.J., Honigberg, I.L., Stewart, J.T., Vallner, J.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	biological fluids Blood Cells - metabolism Chromatography, High Pressure Liquid Dantrolene - analysis Dantrolene - blood Dantrolene - urine dantrolene sodium Dantrolene sodium-high-pressure liquid Chromatographic analysis Dantrolene sodium—high-pressure liquid chromatographic analysis, biological fluids high-pressure liquid Chromatographic analysis High-pressure liquid chromatography-analysis High-pressure liquid chromatography—analysis, dantrolene sodium, biological fluids Humans Hydantoins - analysis Methods Relaxants Relaxants, skeletal muscle—dantrolene sodium, high-pressure liquid chromatographic analysis, biological fluids skeletal muscle-dantrolene sodium Spectrometry, Fluorescence
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Beschreibung
Zusammenfassung:	Dantrolene sodium can be determined in plasma and urine samples by high-pressure liquid chromatography without interference from its two major metabolites, the hydroxy and acetamido compounds. The minimum detectability of the drug using this procedure is 8ng. The complete assay including extraction, evaporation, and separation steps can he performed in approximately 70min with an accuracy of 1–3%.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600660543