Methotrexate analogs. 8. Synthesis and biological evaluation of bisamide derivatives as potential prodrugs

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1977-07, Vol.20 (7), p.925-930
Hauptverfasser:	Rosowsky, Andre, Ensminger, William D, Lazarus, Herbert, Yu, Cheng-Sein
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemical synthesis Amides - metabolism Amides - pharmacology Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Cells, Cultured Chromatography, Thin Layer Folic Acid Antagonists Humans Lactobacillus casei - enzymology Leukemia L1210 - metabolism Leukemia, Experimental - metabolism Leukemia, Lymphoid - metabolism Liver - metabolism Methotrexate - analogs & derivatives Methotrexate - chemical synthesis Methotrexate - metabolism Methotrexate - pharmacology Mice Rats
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