Rubella Complement Fixation Test

Rubella Complement Fixation Test

Complement-fixing antigens specific for rubella were made in tissue cultures of RK-13 rabbit kidney cells and primary cultures of kidney from the African green monkey. The antigens were prepared with the infected cell monolayer diluted to 30 percent with supernatant fluid and frozen and thawed three...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1965-04, Vol.148 (3668), p.385-387
Hauptverfasser: Sever, John L., Huebner, Robert T., Castellano, Gabriel A., Sarma, Padman S., Fabiyl, Akinyele, Schiff, Gilbert M., Cusumano, Charles L.
Format: Artikel
Sprache:eng
Schlagworte:
African culture
Animals
Antibodies
Antigens
Cercopithecus aethiops
Complement Fixation Tests
Complement System Proteins
Cultured cells
Exanthema
Haplorhini
Haptens
Humans
Kidney
Kidneys
Molecules
Neutralization Tests
Old Medline
Rabbits
Research Design
Rubella
Tissue Culture Techniques
Virus Cultivation
Viruses
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Zusammenfassung:Complement-fixing antigens specific for rubella were made in tissue cultures of RK-13 rabbit kidney cells and primary cultures of kidney from the African green monkey. The antigens were prepared with the infected cell monolayer diluted to 30 percent with supernatant fluid and frozen and thawed three times. Complement-fixing antibody appeared in patients with rubella soon after the termination of rash and persisted for at least 8 months. In 8 out of 12 individuals who had the disease 10 to 20 years before they were tested, no complement-fixing antibody was found, but neutralizing antibody was present.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.148.3668.385