A Bactericidal Effect for Human Lactoferrin

A Bactericidal Effect for Human Lactoferrin

Streptococcus mutans and Vibrio cholerae, but not Escherichia coli, were killed by incubation with purified human apolactoferrin. Concentrations of lactoferrin below that necessary for total inhibition resulted in a marked reduction in viable colony-forming units. This bactericidal effect was contin...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1977-07, Vol.197 (4300), p.263-265
Hauptverfasser: Arnold, Roland R., Cole, Michael F., McGhee, Jerry R.
Format: Artikel
Sprache:eng
Schlagworte:
Antiserum
Apoproteins - pharmacology
Atoms
Bacteria
Chelating Agents - pharmacology
Chromosomes
Dose-Response Relationship, Drug
Escherichia coli
Escherichia coli - drug effects
Humans
Iron - metabolism
Lactoferrin - pharmacology
Lactoglobulins - pharmacology
Lipids
Secretion
Species Specificity
Streptococcus - drug effects
Streptococcus mutans
Streptococcus mutans - drug effects
Tissue culture techniques
Vibrio cholerae
Vibrio cholerae - drug effects
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Zusammenfassung:Streptococcus mutans and Vibrio cholerae, but not Escherichia coli, were killed by incubation with purified human apolactoferrin. Concentrations of lactoferrin below that necessary for total inhibition resulted in a marked reduction in viable colony-forming units. This bactericidal effect was contingent upon the metal-chelating properties of the lactoferrin molecule.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.327545