Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia
Background Persons with intellectual disability (ID) and sleep problems exhibit more daytime challenging behaviours than persons with ID without sleep problems. Several anecdotal reports suggest that melatonin is not only effective in the treatment of insomnia, but also decreases daytime challengin...
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| Veröffentlicht in: | Journal of intellectual disability research 2010-01, Vol.54 (1), p.52-59 |
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| container_title | Journal of intellectual disability research |
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| creator | Braam, W. Didden, R. Maas, A. P. H. M. Korzilius, H. Smits, M. G. Curfs, L. M. G. |
| description | Background Persons with intellectual disability (ID) and sleep problems exhibit more daytime challenging behaviours than persons with ID without sleep problems. Several anecdotal reports suggest that melatonin is not only effective in the treatment of insomnia, but also decreases daytime challenging behaviour. However, the effect of melatonin treatment on daytime challenging behaviour in persons with ID has not been investigated in a randomised controlled trial.
Method We investigated the effects of melatonin on challenging behaviour using data from two randomised controlled trials on the efficacy of melatonin on sleep problems in 49 persons (25 men, 24 women; mean age 18.2 years, SD = 17.1) with ID and chronic insomnia. Participants received either melatonin 5 mg ( |
| doi_str_mv | 10.1111/j.1365-2788.2009.01223.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_839578547</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ericid>EJ867577</ericid><sourcerecordid>1926403441</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5363-15459884f0eef9439eeb4b4e99155aecc37ebe9c9c1e43908560fe677e33d17a3</originalsourceid><addsrcrecordid>eNqNkUtv1DAUhS1ERYfCP0AoYsMqwY7j14IFGtrSUQFR8VhajnPT8ZDH1E7ozL_HIaOpxAaycazzneNrH4QSgjMSvzebjFDO0lxImeUYqwyTPKfZ7hFaHIXHaIEVL9KcU3qKnoawwRhzUvAn6JQoKaXKyQJ1H6ExQ9-5LqnAejABQlKZ_eBaSOzaNA10t667TUpYm1-uH30S0S340HchuXfDOu4HiJgdRtMklQumdI0b9onpqpjgY7aNTOjbzpln6KQ2TYDnh_UMfbs4_7r8kF5_vrxavrtOLaOcpoQVLI5Y1BigVgVVAGVRFqAUYcyAtVRACcoqSyCqWDKOa-BCAKUVEYaeoddz7tb3dyOEQbcu2Dim6aAfg5ZUMSFZIf5JCkoVJRhP5Ku_yE18ji5eQ-e5FJzJXEZIzpD1fQgear31rjV-rwnWU3d6o6eK9FSRnrrTf7rTu2h9ecgfyxaqB-OhrAi8mAHwzh7l85XkgolpvrezfO8a2P_3uXp1dTP9RX86-10YYHf0G_9Tc0EF0z8-XeoVu3j_fclu9Bf6G_5JwY0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>228765828</pqid></control><display><type>article</type><title>Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>MEDLINE</source><source>Education Source</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Braam, W. ; Didden, R. ; Maas, A. P. H. M. ; Korzilius, H. ; Smits, M. G. ; Curfs, L. M. G.</creator><creatorcontrib>Braam, W. ; Didden, R. ; Maas, A. P. H. M. ; Korzilius, H. ; Smits, M. G. ; Curfs, L. M. G.</creatorcontrib><description>Background Persons with intellectual disability (ID) and sleep problems exhibit more daytime challenging behaviours than persons with ID without sleep problems. Several anecdotal reports suggest that melatonin is not only effective in the treatment of insomnia, but also decreases daytime challenging behaviour. However, the effect of melatonin treatment on daytime challenging behaviour in persons with ID has not been investigated in a randomised controlled trial.
Method We investigated the effects of melatonin on challenging behaviour using data from two randomised controlled trials on the efficacy of melatonin on sleep problems in 49 persons (25 men, 24 women; mean age 18.2 years, SD = 17.1) with ID and chronic insomnia. Participants received either melatonin 5 mg (<6 years 2.5 mg) or placebo during 4 weeks. Daytime challenging behaviour was measured by the Storend Gedragsschaal voor Zwakzinnigen – Maladaptive Behaviour Scale for the Mentally Retarded (SGZ; Kraijer & Kema, 1994) at baseline week and the end of the fourth treatment week. Salivary dim light melatonin onset (DLMO) was measured at baseline and the last day of the fourth treatment week. Sleep logs were used to gather information on sleep parameters.
Results Melatonin treatment significantly reduced SGZ scores, sleep latency, and number and duration of night wakes, and treatment increased total sleep time and advanced DLMO. However, after 4 weeks of treatment, change in SGZ scores did not significantly correlate with change in sleep parameters, nor with change in DLMO. Relatively strong correlations were found between change in SGZ scores, change in DLMO and number of night wakes.
Conclusions Melatonin treatment in persons with ID and chronic insomnia decreases daytime challenging behaviour, probably by improving sleep maintenance or by improving circadian melatonin rhythmicity.</description><identifier>ISSN: 0964-2633</identifier><identifier>EISSN: 1365-2788</identifier><identifier>DOI: 10.1111/j.1365-2788.2009.01223.x</identifier><identifier>PMID: 19888921</identifier><identifier>CODEN: JIDREN</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Behavior ; Behavior Modification ; Behavior Problems ; Challenging behaviour ; Child ; Child, Preschool ; Chronic Disease ; Chronic insomnia ; Circadian Rhythm - drug effects ; Clinical trials ; Comparative Analysis ; Correlation ; Correlation analysis ; Developmental disabilities ; dim light melatonin onset ; Drug Therapy ; Female ; Hormones ; Humans ; Insomnia ; Intellectual Disability ; Intellectual Disability - drug therapy ; Intellectual Disability - psychology ; Learning disabilities ; Male ; Melatonin ; Melatonin - blood ; Melatonin - therapeutic use ; Mental Retardation ; Middle Aged ; Randomized Controlled Trials as Topic ; Sleep ; Sleep - drug effects ; Sleep Initiation and Maintenance Disorders - drug therapy ; Sleep Initiation and Maintenance Disorders - psychology ; Sleep problems ; Social Behavior Disorders - drug therapy ; Social Behavior Disorders - psychology ; Wakefulness - drug effects</subject><ispartof>Journal of intellectual disability research, 2010-01, Vol.54 (1), p.52-59</ispartof><rights>2009 The Authors. Journal Compilation © 2009 Blackwell Publishing Ltd</rights><rights>Copyright Blackwell Publishing Ltd. Jan 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5363-15459884f0eef9439eeb4b4e99155aecc37ebe9c9c1e43908560fe677e33d17a3</citedby><cites>FETCH-LOGICAL-c5363-15459884f0eef9439eeb4b4e99155aecc37ebe9c9c1e43908560fe677e33d17a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2788.2009.01223.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2788.2009.01223.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,30976,30977,45550,45551</link.rule.ids><backlink>$$Uhttp://eric.ed.gov/ERICWebPortal/detail?accno=EJ867577$$DView record in ERIC$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19888921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Braam, W.</creatorcontrib><creatorcontrib>Didden, R.</creatorcontrib><creatorcontrib>Maas, A. P. H. M.</creatorcontrib><creatorcontrib>Korzilius, H.</creatorcontrib><creatorcontrib>Smits, M. G.</creatorcontrib><creatorcontrib>Curfs, L. M. G.</creatorcontrib><title>Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia</title><title>Journal of intellectual disability research</title><addtitle>J Intellect Disabil Res</addtitle><description>Background Persons with intellectual disability (ID) and sleep problems exhibit more daytime challenging behaviours than persons with ID without sleep problems. Several anecdotal reports suggest that melatonin is not only effective in the treatment of insomnia, but also decreases daytime challenging behaviour. However, the effect of melatonin treatment on daytime challenging behaviour in persons with ID has not been investigated in a randomised controlled trial.
Method We investigated the effects of melatonin on challenging behaviour using data from two randomised controlled trials on the efficacy of melatonin on sleep problems in 49 persons (25 men, 24 women; mean age 18.2 years, SD = 17.1) with ID and chronic insomnia. Participants received either melatonin 5 mg (<6 years 2.5 mg) or placebo during 4 weeks. Daytime challenging behaviour was measured by the Storend Gedragsschaal voor Zwakzinnigen – Maladaptive Behaviour Scale for the Mentally Retarded (SGZ; Kraijer & Kema, 1994) at baseline week and the end of the fourth treatment week. Salivary dim light melatonin onset (DLMO) was measured at baseline and the last day of the fourth treatment week. Sleep logs were used to gather information on sleep parameters.
Results Melatonin treatment significantly reduced SGZ scores, sleep latency, and number and duration of night wakes, and treatment increased total sleep time and advanced DLMO. However, after 4 weeks of treatment, change in SGZ scores did not significantly correlate with change in sleep parameters, nor with change in DLMO. Relatively strong correlations were found between change in SGZ scores, change in DLMO and number of night wakes.
Conclusions Melatonin treatment in persons with ID and chronic insomnia decreases daytime challenging behaviour, probably by improving sleep maintenance or by improving circadian melatonin rhythmicity.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Behavior</subject><subject>Behavior Modification</subject><subject>Behavior Problems</subject><subject>Challenging behaviour</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chronic Disease</subject><subject>Chronic insomnia</subject><subject>Circadian Rhythm - drug effects</subject><subject>Clinical trials</subject><subject>Comparative Analysis</subject><subject>Correlation</subject><subject>Correlation analysis</subject><subject>Developmental disabilities</subject><subject>dim light melatonin onset</subject><subject>Drug Therapy</subject><subject>Female</subject><subject>Hormones</subject><subject>Humans</subject><subject>Insomnia</subject><subject>Intellectual Disability</subject><subject>Intellectual Disability - drug therapy</subject><subject>Intellectual Disability - psychology</subject><subject>Learning disabilities</subject><subject>Male</subject><subject>Melatonin</subject><subject>Melatonin - blood</subject><subject>Melatonin - therapeutic use</subject><subject>Mental Retardation</subject><subject>Middle Aged</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Sleep</subject><subject>Sleep - drug effects</subject><subject>Sleep Initiation and Maintenance Disorders - drug therapy</subject><subject>Sleep Initiation and Maintenance Disorders - psychology</subject><subject>Sleep problems</subject><subject>Social Behavior Disorders - drug therapy</subject><subject>Social Behavior Disorders - psychology</subject><subject>Wakefulness - drug effects</subject><issn>0964-2633</issn><issn>1365-2788</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkUtv1DAUhS1ERYfCP0AoYsMqwY7j14IFGtrSUQFR8VhajnPT8ZDH1E7ozL_HIaOpxAaycazzneNrH4QSgjMSvzebjFDO0lxImeUYqwyTPKfZ7hFaHIXHaIEVL9KcU3qKnoawwRhzUvAn6JQoKaXKyQJ1H6ExQ9-5LqnAejABQlKZ_eBaSOzaNA10t667TUpYm1-uH30S0S340HchuXfDOu4HiJgdRtMklQumdI0b9onpqpjgY7aNTOjbzpln6KQ2TYDnh_UMfbs4_7r8kF5_vrxavrtOLaOcpoQVLI5Y1BigVgVVAGVRFqAUYcyAtVRACcoqSyCqWDKOa-BCAKUVEYaeoddz7tb3dyOEQbcu2Dim6aAfg5ZUMSFZIf5JCkoVJRhP5Ku_yE18ji5eQ-e5FJzJXEZIzpD1fQgear31rjV-rwnWU3d6o6eK9FSRnrrTf7rTu2h9ecgfyxaqB-OhrAi8mAHwzh7l85XkgolpvrezfO8a2P_3uXp1dTP9RX86-10YYHf0G_9Tc0EF0z8-XeoVu3j_fclu9Bf6G_5JwY0</recordid><startdate>201001</startdate><enddate>201001</enddate><creator>Braam, W.</creator><creator>Didden, R.</creator><creator>Maas, A. P. H. M.</creator><creator>Korzilius, H.</creator><creator>Smits, M. G.</creator><creator>Curfs, L. M. G.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>7SW</scope><scope>BJH</scope><scope>BNH</scope><scope>BNI</scope><scope>BNJ</scope><scope>BNO</scope><scope>ERI</scope><scope>PET</scope><scope>REK</scope><scope>WWN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7X8</scope></search><sort><creationdate>201001</creationdate><title>Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia</title><author>Braam, W. ; Didden, R. ; Maas, A. P. H. M. ; Korzilius, H. ; Smits, M. G. ; Curfs, L. M. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5363-15459884f0eef9439eeb4b4e99155aecc37ebe9c9c1e43908560fe677e33d17a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Behavior</topic><topic>Behavior Modification</topic><topic>Behavior Problems</topic><topic>Challenging behaviour</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chronic Disease</topic><topic>Chronic insomnia</topic><topic>Circadian Rhythm - drug effects</topic><topic>Clinical trials</topic><topic>Comparative Analysis</topic><topic>Correlation</topic><topic>Correlation analysis</topic><topic>Developmental disabilities</topic><topic>dim light melatonin onset</topic><topic>Drug Therapy</topic><topic>Female</topic><topic>Hormones</topic><topic>Humans</topic><topic>Insomnia</topic><topic>Intellectual Disability</topic><topic>Intellectual Disability - drug therapy</topic><topic>Intellectual Disability - psychology</topic><topic>Learning disabilities</topic><topic>Male</topic><topic>Melatonin</topic><topic>Melatonin - blood</topic><topic>Melatonin - therapeutic use</topic><topic>Mental Retardation</topic><topic>Middle Aged</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Sleep</topic><topic>Sleep - drug effects</topic><topic>Sleep Initiation and Maintenance Disorders - drug therapy</topic><topic>Sleep Initiation and Maintenance Disorders - psychology</topic><topic>Sleep problems</topic><topic>Social Behavior Disorders - drug therapy</topic><topic>Social Behavior Disorders - psychology</topic><topic>Wakefulness - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Braam, W.</creatorcontrib><creatorcontrib>Didden, R.</creatorcontrib><creatorcontrib>Maas, A. P. H. M.</creatorcontrib><creatorcontrib>Korzilius, H.</creatorcontrib><creatorcontrib>Smits, M. G.</creatorcontrib><creatorcontrib>Curfs, L. M. G.</creatorcontrib><collection>Istex</collection><collection>ERIC</collection><collection>ERIC (Ovid)</collection><collection>ERIC</collection><collection>ERIC</collection><collection>ERIC (Legacy Platform)</collection><collection>ERIC( SilverPlatter )</collection><collection>ERIC</collection><collection>ERIC PlusText (Legacy Platform)</collection><collection>Education Resources Information Center (ERIC)</collection><collection>ERIC</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of intellectual disability research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Braam, W.</au><au>Didden, R.</au><au>Maas, A. P. H. M.</au><au>Korzilius, H.</au><au>Smits, M. G.</au><au>Curfs, L. M. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><ericid>EJ867577</ericid><atitle>Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia</atitle><jtitle>Journal of intellectual disability research</jtitle><addtitle>J Intellect Disabil Res</addtitle><date>2010-01</date><risdate>2010</risdate><volume>54</volume><issue>1</issue><spage>52</spage><epage>59</epage><pages>52-59</pages><issn>0964-2633</issn><eissn>1365-2788</eissn><coden>JIDREN</coden><abstract>Background Persons with intellectual disability (ID) and sleep problems exhibit more daytime challenging behaviours than persons with ID without sleep problems. Several anecdotal reports suggest that melatonin is not only effective in the treatment of insomnia, but also decreases daytime challenging behaviour. However, the effect of melatonin treatment on daytime challenging behaviour in persons with ID has not been investigated in a randomised controlled trial.
Method We investigated the effects of melatonin on challenging behaviour using data from two randomised controlled trials on the efficacy of melatonin on sleep problems in 49 persons (25 men, 24 women; mean age 18.2 years, SD = 17.1) with ID and chronic insomnia. Participants received either melatonin 5 mg (<6 years 2.5 mg) or placebo during 4 weeks. Daytime challenging behaviour was measured by the Storend Gedragsschaal voor Zwakzinnigen – Maladaptive Behaviour Scale for the Mentally Retarded (SGZ; Kraijer & Kema, 1994) at baseline week and the end of the fourth treatment week. Salivary dim light melatonin onset (DLMO) was measured at baseline and the last day of the fourth treatment week. Sleep logs were used to gather information on sleep parameters.
Results Melatonin treatment significantly reduced SGZ scores, sleep latency, and number and duration of night wakes, and treatment increased total sleep time and advanced DLMO. However, after 4 weeks of treatment, change in SGZ scores did not significantly correlate with change in sleep parameters, nor with change in DLMO. Relatively strong correlations were found between change in SGZ scores, change in DLMO and number of night wakes.
Conclusions Melatonin treatment in persons with ID and chronic insomnia decreases daytime challenging behaviour, probably by improving sleep maintenance or by improving circadian melatonin rhythmicity.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19888921</pmid><doi>10.1111/j.1365-2788.2009.01223.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Education Source; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Behavior Behavior Modification Behavior Problems Challenging behaviour Child Child, Preschool Chronic Disease Chronic insomnia Circadian Rhythm - drug effects Clinical trials Comparative Analysis Correlation Correlation analysis Developmental disabilities dim light melatonin onset Drug Therapy Female Hormones Humans Insomnia Intellectual Disability Intellectual Disability - drug therapy Intellectual Disability - psychology Learning disabilities Male Melatonin Melatonin - blood Melatonin - therapeutic use Mental Retardation Middle Aged Randomized Controlled Trials as Topic Sleep Sleep - drug effects Sleep Initiation and Maintenance Disorders - drug therapy Sleep Initiation and Maintenance Disorders - psychology Sleep problems Social Behavior Disorders - drug therapy Social Behavior Disorders - psychology Wakefulness - drug effects |
| title | Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia |
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