Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia

Background Persons with intellectual disability (ID) and sleep problems exhibit more daytime challenging behaviours than persons with ID without sleep problems. Several anecdotal reports suggest that melatonin is not only effective in the treatment of insomnia, but also decreases daytime challengin...

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Veröffentlicht in:	Journal of intellectual disability research 2010-01, Vol.54 (1), p.52-59
Hauptverfasser:	Braam, W., Didden, R., Maas, A. P. H. M., Korzilius, H., Smits, M. G., Curfs, L. M. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Behavior Behavior Modification Behavior Problems Challenging behaviour Child Child, Preschool Chronic Disease Chronic insomnia Circadian Rhythm - drug effects Clinical trials Comparative Analysis Correlation Correlation analysis Developmental disabilities dim light melatonin onset Drug Therapy Female Hormones Humans Insomnia Intellectual Disability Intellectual Disability - drug therapy Intellectual Disability - psychology Learning disabilities Male Melatonin Melatonin - blood Melatonin - therapeutic use Mental Retardation Middle Aged Randomized Controlled Trials as Topic Sleep Sleep - drug effects Sleep Initiation and Maintenance Disorders - drug therapy Sleep Initiation and Maintenance Disorders - psychology Sleep problems Social Behavior Disorders - drug therapy Social Behavior Disorders - psychology Wakefulness - drug effects
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Zusammenfassung:	Background Persons with intellectual disability (ID) and sleep problems exhibit more daytime challenging behaviours than persons with ID without sleep problems. Several anecdotal reports suggest that melatonin is not only effective in the treatment of insomnia, but also decreases daytime challenging behaviour. However, the effect of melatonin treatment on daytime challenging behaviour in persons with ID has not been investigated in a randomised controlled trial. Method We investigated the effects of melatonin on challenging behaviour using data from two randomised controlled trials on the efficacy of melatonin on sleep problems in 49 persons (25 men, 24 women; mean age 18.2 years, SD = 17.1) with ID and chronic insomnia. Participants received either melatonin 5 mg (
ISSN:	0964-2633 1365-2788
DOI:	10.1111/j.1365-2788.2009.01223.x