Peptides Attached to Thrombin: Their Influence on Proteolysis
During the activation of prothrombin at least two peptides are split off the molecule. These peptides become attached to thrombin, changing its proteolytic activity. Depending on the peptide adsorbed the endopeptidase activity of thrombin increases or diminishes. Acidification of thrombin by acetyla...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1965-04, Vol.148 (3668), p.380-381 |
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| container_end_page | 381 |
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| container_issue | 3668 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 148 |
| creator | Landaburu, Richardo H. Abdala, Osvaldo Morrone, Jorge |
| description | During the activation of prothrombin at least two peptides are split off the molecule. These peptides become attached to thrombin, changing its proteolytic activity. Depending on the peptide adsorbed the endopeptidase activity of thrombin increases or diminishes. Acidification of thrombin by acetylation of amino groups uncovers the influence of peptides on the properties of thrombin. |
| doi_str_mv | 10.1126/science.148.3668.380 |
| format | Article |
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These peptides become attached to thrombin, changing its proteolytic activity. Depending on the peptide adsorbed the endopeptidase activity of thrombin increases or diminishes. Acidification of thrombin by acetylation of amino groups uncovers the influence of peptides on the properties of thrombin.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.148.3668.380</identifier><identifier>PMID: 14261532</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Acetylation ; Adsorption ; Amino acids ; Blood Coagulation ; Calcium ; Chemical Phenomena ; Chemistry ; Clotting ; Esterases ; Free radicals ; Humans ; Metal ions ; Molecules ; Old Medline ; Peptide Hydrolases ; Peptides ; Phosphates ; Proteins ; Proteolysis ; Prothrombin ; Thrombin</subject><ispartof>Science (American Association for the Advancement of Science), 1965-04, Vol.148 (3668), p.380-381</ispartof><rights>Copyright 1965 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-bf52f0328adac058c201e2bcf3efaee7c7043e74e649ca968d24b7c485319bf33</citedby><cites>FETCH-LOGICAL-c356t-bf52f0328adac058c201e2bcf3efaee7c7043e74e649ca968d24b7c485319bf33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1715099$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1715099$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2870,2871,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14261532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Landaburu, Richardo H.</creatorcontrib><creatorcontrib>Abdala, Osvaldo</creatorcontrib><creatorcontrib>Morrone, Jorge</creatorcontrib><title>Peptides Attached to Thrombin: Their Influence on Proteolysis</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>During the activation of prothrombin at least two peptides are split off the molecule. These peptides become attached to thrombin, changing its proteolytic activity. Depending on the peptide adsorbed the endopeptidase activity of thrombin increases or diminishes. Acidification of thrombin by acetylation of amino groups uncovers the influence of peptides on the properties of thrombin.</description><subject>Acetylation</subject><subject>Adsorption</subject><subject>Amino acids</subject><subject>Blood Coagulation</subject><subject>Calcium</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Clotting</subject><subject>Esterases</subject><subject>Free radicals</subject><subject>Humans</subject><subject>Metal ions</subject><subject>Molecules</subject><subject>Old Medline</subject><subject>Peptide Hydrolases</subject><subject>Peptides</subject><subject>Phosphates</subject><subject>Proteins</subject><subject>Proteolysis</subject><subject>Prothrombin</subject><subject>Thrombin</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1965</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMlqwzAQhkVpadK0bxCKT7051WpLhR5C6BIINIf0LGx5RBxsK5XsQ96-CjHkMjPwLwMfQnOCF4TQ7DWYGjoDC8LlgmVZHBLfoCnBSqSKYnaLphizLJU4FxP0EMIB46gpdo8mhNOMCEan6H0Lx76uICTLvi_MHqqkd8lu711b1t1bvKD2ybqzzXD-lrgu2XrXg2tOoQ6P6M4WTYCncc_Q7-fHbvWdbn6-1qvlJjVMZH1aWkEtZlQWVWGwkIZiArQ0loEtAHKTY84g55BxZQqVyYryMjdcCkZUaRmboZdL79G7vwFCr9s6GGiaogM3BC2Z4pIyFY38YjTeheDB6qOv28KfNMH6jE2P2HTEps_YdMQWY89j_1C2UF1DI6domF8Mh9A7f9VzIrBS7B-9znQW</recordid><startdate>19650416</startdate><enddate>19650416</enddate><creator>Landaburu, Richardo H.</creator><creator>Abdala, Osvaldo</creator><creator>Morrone, Jorge</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19650416</creationdate><title>Peptides Attached to Thrombin: Their Influence on Proteolysis</title><author>Landaburu, Richardo H. ; Abdala, Osvaldo ; Morrone, Jorge</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-bf52f0328adac058c201e2bcf3efaee7c7043e74e649ca968d24b7c485319bf33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1965</creationdate><topic>Acetylation</topic><topic>Adsorption</topic><topic>Amino acids</topic><topic>Blood Coagulation</topic><topic>Calcium</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Clotting</topic><topic>Esterases</topic><topic>Free radicals</topic><topic>Humans</topic><topic>Metal ions</topic><topic>Molecules</topic><topic>Old Medline</topic><topic>Peptide Hydrolases</topic><topic>Peptides</topic><topic>Phosphates</topic><topic>Proteins</topic><topic>Proteolysis</topic><topic>Prothrombin</topic><topic>Thrombin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Landaburu, Richardo H.</creatorcontrib><creatorcontrib>Abdala, Osvaldo</creatorcontrib><creatorcontrib>Morrone, Jorge</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Landaburu, Richardo H.</au><au>Abdala, Osvaldo</au><au>Morrone, Jorge</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peptides Attached to Thrombin: Their Influence on Proteolysis</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1965-04-16</date><risdate>1965</risdate><volume>148</volume><issue>3668</issue><spage>380</spage><epage>381</epage><pages>380-381</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>During the activation of prothrombin at least two peptides are split off the molecule. 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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1965-04, Vol.148 (3668), p.380-381 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83948239 |
| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Acetylation Adsorption Amino acids Blood Coagulation Calcium Chemical Phenomena Chemistry Clotting Esterases Free radicals Humans Metal ions Molecules Old Medline Peptide Hydrolases Peptides Phosphates Proteins Proteolysis Prothrombin Thrombin |
| title | Peptides Attached to Thrombin: Their Influence on Proteolysis |
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