Peptides Attached to Thrombin: Their Influence on Proteolysis

Peptides Attached to Thrombin: Their Influence on Proteolysis

During the activation of prothrombin at least two peptides are split off the molecule. These peptides become attached to thrombin, changing its proteolytic activity. Depending on the peptide adsorbed the endopeptidase activity of thrombin increases or diminishes. Acidification of thrombin by acetyla...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1965-04, Vol.148 (3668), p.380-381
Hauptverfasser: Landaburu, Richardo H., Abdala, Osvaldo, Morrone, Jorge
Format: Artikel
Sprache:eng
Schlagworte:
Acetylation
Adsorption
Amino acids
Blood Coagulation
Calcium
Chemical Phenomena
Chemistry
Clotting
Esterases
Free radicals
Humans
Metal ions
Molecules
Old Medline
Peptide Hydrolases
Peptides
Phosphates
Proteins
Proteolysis
Prothrombin
Thrombin
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Beschreibung
Zusammenfassung:During the activation of prothrombin at least two peptides are split off the molecule. These peptides become attached to thrombin, changing its proteolytic activity. Depending on the peptide adsorbed the endopeptidase activity of thrombin increases or diminishes. Acidification of thrombin by acetylation of amino groups uncovers the influence of peptides on the properties of thrombin.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.148.3668.380