Effect of ionic environment on the release of LH from chicken anterior pituitary cells

The release of LH from isolated chicken anterior pituitary cells was affected by the ionic composition of the external medium. High potassium stimulated the release of LH and enhanced the response of LH-RH. The stimulatory effect of high potassium and LH-RH was abolished in the absence of calcium. E...

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Veröffentlicht in:	Molecular and cellular endocrinology 1977-05, Vol.7 (3), p.245-251
Hauptverfasser:	Bonney, Rosemary C., Cunningham, F.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - pharmacology chicken pituitary Chickens Fluorides - pharmacology ionic effects LH secretion Luteinizing Hormone - metabolism Magnesium - pharmacology Pituitary Gland - metabolism Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - metabolism Potassium - pharmacology
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Zusammenfassung:	The release of LH from isolated chicken anterior pituitary cells was affected by the ionic composition of the external medium. High potassium stimulated the release of LH and enhanced the response of LH-RH. The stimulatory effect of high potassium and LH-RH was abolished in the absence of calcium. Excess magnesium inhibited the response to LH-RH. Fluoride at a concentration of 10 −2 M stimulated a maximal release of LH while lower concentrations were without effect. The stimulatory effects of potassium and fluoride emphasize the similarity between the mechanism of action of LH-RH in both the chicken and the mammal.
ISSN:	0303-7207 1872-8057
DOI:	10.1016/0303-7207(77)90056-9