Specific macromolecular binding of estradiol in the mammalian liver supernatant

Specific macromolecular binding of estradiol in the mammalian liver supernatant

The liver supernatant of adult female rats contains proteins with a high specificity for binding radioactive estradiol and other potent estrogens. Several properties of the liver macromolecules are similar to those of the presumed estrogen receptor found in the uterus. Specific estrogen binding is a...

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Veröffentlicht in:Biochemical pharmacology 1977-05, Vol.26 (10), p.919-922
Hauptverfasser: Eisenfeld, Arnold J., Aten, Raymond F., Haselbacher, Gisela K., Halpern, Katherine
Format: Artikel
Sprache:eng
Schlagworte:
4-Chloromercuribenzenesulfonate - pharmacology
Animals
Cercopithecus
Estradiol - metabolism
Female
Haplorhini
In Vitro Techniques
Liver - drug effects
Liver - metabolism
Liver - ultrastructure
Protein Binding
Rabbits
Rats
Steroids - pharmacology
Uterus - metabolism
Uterus - ultrastructure
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Beschreibung
Zusammenfassung:The liver supernatant of adult female rats contains proteins with a high specificity for binding radioactive estradiol and other potent estrogens. Several properties of the liver macromolecules are similar to those of the presumed estrogen receptor found in the uterus. Specific estrogen binding is also present in the liver supernatant of the rabbit and green monkey. Estrogens are known to influence liver composition and function in mammals. The estrogen binding protein observed in the mammalian liver may be an estrogen receptor.
ISSN:0006-2952
1873-2968
DOI:10.1016/0006-2952(77)90466-X