Synthesis of 5,6-Benzo-2-azabicyclo[2.2.2]octane Derivatives as Potential Benzomorphan-Type Analgesic Agents

The synthesis of two N-substituted 5,6-benzo-2-azabicyclo[2.2.2]octane analogs of benzomorphan-type analgesics via benzyne addition to appropriate N-substituted N-alkyl-2-pyridones is described. Neither derivative possessed observable analgesic activity at the doses tested.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1977-04, Vol.66 (4), p.594-596
Hauptverfasser:	Borne, Ronald F., Law, Say-Jong, Wirth, Philip W., Murphy, James C.
Format:	Artikel
Sprache:	eng
Schlagworte:	5,6-Benzo-2-azabicyclo[2.2.2]octanes, N-substituted—synthesized, analgesic activity evaluated, mice 6-Benzo-2-azabicyclo[2.2.2]octanes 6-benzo-2-azabicyclo[2.2.2]octanes evaluated 6-benzo-2-azabicyclo[2.2.2]octanes synthesized analgesic activity evaluated Analgesic activity-N-substituted 5 Analgesic activity—N-substituted 5,6-benzo-2-azabicyclo[2.2.2]octanes evaluated, mice Analgesics - chemical synthesis Animals Aza Compounds - chemical synthesis Aza Compounds - pharmacology Behavior, Animal - drug effects Benzomorphans - analogs & derivatives Bridged Bicyclo Compounds - chemical synthesis Bridged Bicyclo Compounds - pharmacology Bridged-Ring Compounds - chemical synthesis Male Mice Morphinans - analogs & derivatives N-substituted-synthesized Structure-activity relationships-N-substituted 5 Structure-activity relationships—N-substituted 5,6-benzo-2-azabicyclo[2.2.2]octanes synthesized, analgesic activity evaluated, mice
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The synthesis of two N-substituted 5,6-benzo-2-azabicyclo[2.2.2]octane analogs of benzomorphan-type analgesics via benzyne addition to appropriate N-substituted N-alkyl-2-pyridones is described. Neither derivative possessed observable analgesic activity at the doses tested.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600660438