Mathematical Basis of Point–Area Deconvolution Method for Determining In Vivo Input Functions

The point–area method for deconvolution derives a “staircase” input function which, when convolved onto the characteristic function, gives an output function coincidental with the given output data points. The area-area method for deconvolution is shown to be erroneous.

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Veröffentlicht in:	Journal of pharmaceutical sciences 1978-05, Vol.67 (5), p.663-665
Hauptverfasser:	Vaughan, D.P., Dennis, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Deconvolution-point-area and area-area methods for determining in vivo input functions compared in vivo-deconvolution point-area and area-area methods of determination compared Input functions Input functions in vivo—deconvolution point-area and area-area methods of determination compared Mathematics Models, Biological Pharmaceutical Preparations - metabolism Pharmacokinetics-deconvolution point-area and area-area methods for determining in vivo input functions compared Solubility
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Beschreibung
Zusammenfassung:	The point–area method for deconvolution derives a “staircase” input function which, when convolved onto the characteristic function, gives an output function coincidental with the given output data points. The area-area method for deconvolution is shown to be erroneous.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600670524