Simple and Rapid High-pressure Liquid Chromatographic Simultaneous Determination of Aspirin, Salicylic Acid, and Salicyluric Acid in Plasma

A rapid and sensitive high-pressure liquid chromatographic assay was developed for aspirin, salicylic acid, and salicyluric acid in plasma. The procedure involves the solvent extraction of these compounds from plasma and separation using a reversed-phase column eluted by acidified aqueous acetonitri...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1978-05, Vol.67 (5), p.710-712
Hauptverfasser:	Peng, Geoffrey W., Gadalla, M.A.F., Pmith, Vicky, Peng, Anna, Chiou, Win L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics-aspirin Analgesics—aspirin salicylic acid, and salicyluric acid, simultaneous high-pressure liquid chromatographic analyses in plasma and salicyluric acid and salicyluric acid simultaneously in plasma aspirin Aspirin - blood Aspirin-high-pressure liquid chromatographic analysis in plasma simultaneously with salicylic acid and salicyluric acid Chromatography, High Pressure Liquid High-pressure liquid chromatography-analyses High‐pressure liquid chromatography—analyses, aspirin, salicylic acid, and salicyluric acid simultaneously in plasma Hippurates - blood Methods Salicylates - blood salicylic acid Salicylic acid-high-pressure liquid chromatographic analysis in plasma simultaneously with aspirin and salicyluric acid Salicyluric acid high—pressure liquid chromatographic analysis in plasma simultaneously with aspirin and salicylic acid simultaneous high-pressure liquid chromatographic analyses in plasma Time Factors
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Beschreibung
Zusammenfassung:	A rapid and sensitive high-pressure liquid chromatographic assay was developed for aspirin, salicylic acid, and salicyluric acid in plasma. The procedure involves the solvent extraction of these compounds from plasma and separation using a reversed-phase column eluted by acidified aqueous acetonitrile. Small quantities of aspirin can be assayed directly in the presence of a large quantity of salicylic acid. The assay is also free from blank interference.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600670540