Isolation of amyloid P component (protein AP) from normal serum as a calcium-dependent binding protein

Isolation of amyloid P component (protein AP) from normal serum as a calcium-dependent binding protein

The P component of amyloid (protein AP, pentagonal unit) has been isolated from normal serum by using its hitherto undescribed calcium-dependent affinity for agarose. The presence of P component in all forms of amyloid may be due to this calcium-dependent binding to certain polyanions.

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Bibliographische Detailangaben
Veröffentlicht in:The Lancet (British edition) 1977-05, Vol.1 (8020), p.1029-1031
Hauptverfasser: Pepys, M B, Dash, A C
Format: Artikel
Sprache:eng
Schlagworte:
Amyloid - analysis
Amyloid - immunology
Blood Proteins - isolation & purification
Calcium
Carrier Proteins - isolation & purification
Complement C1 - isolation & purification
Complement System Proteins - isolation & purification
Electrophoresis, Polyacrylamide Gel
Humans
Immunodiffusion
Immunoelectrophoresis
Microscopy, Electron
Protein Binding
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Zusammenfassung:The P component of amyloid (protein AP, pentagonal unit) has been isolated from normal serum by using its hitherto undescribed calcium-dependent affinity for agarose. The presence of P component in all forms of amyloid may be due to this calcium-dependent binding to certain polyanions.
ISSN:0140-6736