Muscular Dystrophy: Inhibition of Degeneration in vivo with Protease Inhibitors

The protease inhibitors leupeptin and pepstatin were used in vivo in genetically dystrophic chickens to determine their effects on the histological and biochemical changes observed in this disease. These compounds appear to delay the degeneration of muscle tissue which is characteristic of this diso...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1978-04, Vol.200 (4337), p.50-51
Hauptverfasser:	Stracher, A., McGowan, E. B., Shafiq, S. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chickens Chicks Creatine Kinase - blood Enzymes Histology Leupeptins - therapeutic use Muscle tissues Muscles Muscles - pathology Muscular diseases Muscular disorders Muscular dystrophies Muscular Dystrophy, Animal - drug therapy Muscular Dystrophy, Animal - enzymology Muscular Dystrophy, Animal - pathology Nervous system diseases Oligopeptides - therapeutic use Pepstatins - therapeutic use Protease inhibitors
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Beschreibung
Zusammenfassung:	The protease inhibitors leupeptin and pepstatin were used in vivo in genetically dystrophic chickens to determine their effects on the histological and biochemical changes observed in this disease. These compounds appear to delay the degeneration of muscle tissue which is characteristic of this disorder and thus may have potential therapeutic value in the treatment of muscular dystrophy.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.635570