Synthesis of an anti-inflammatory 10,10a-dihydro-1H,5H-imidazo[1,5-b)isoquinoline-1,3(2H)-dione

Synthesis of an anti-inflammatory 10,10a-dihydro-1H,5H-imidazo[1,5-b)isoquinoline-1,3(2H)-dione

A new synthesis of imidazo[1,5-b]isoquinolines is reported. 2-[2-(Piperidino)ethyl]-10,10a-dihydro-1H,5H-imidazo[1,5-b]isoquinoline-1,3(2H)-dione hydrochloride was found to posses anti-inflammatory activity.

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Veröffentlicht in:Journal of pharmaceutical sciences 1978-05, Vol.67 (5), p.718-719
Hauptverfasser: Schwan, T J, Goldenberg, M M, Ilse, A C
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Inflammatory Agents - chemical synthesis
Isoquinolines - chemical synthesis
Isoquinolines - pharmacology
Methods
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Zusammenfassung:A new synthesis of imidazo[1,5-b]isoquinolines is reported. 2-[2-(Piperidino)ethyl]-10,10a-dihydro-1H,5H-imidazo[1,5-b]isoquinoline-1,3(2H)-dione hydrochloride was found to posses anti-inflammatory activity.
ISSN:0022-3549