Synthesis of 2-(Substituted Anilino) 4-(Substituted Phenyl)thiazoles

2-(Substituted anilino) 4-(substituted phenyl)thiazoles were synthesized by condensing 2-haloketones with substituted thioureas. The biological screening of some compounds indicated hypoglycemic and hyperglycemic activity.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1978-04, Vol.67 (4), p.587-589
Hauptverfasser:	Thakar, K.A., Goswami, D.D., Choudhari, S.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - chemical synthesis Aniline Compounds - pharmacology Animals Blood Glucose - metabolism evaluated for hypoglycemic and hyperglycemic activity Hyperglycemic activity-various substituted thiazoles evaluated Hypoglycemic activity-various substituted thiazoles evaluated Rats Structure-activity relationships-various substituted thiazoles evaluated for hypoglycemic and hyperglycemic activity Thiazoles Thiazoles - chemical synthesis Thiazoles - pharmacology Thiazoles various substituted—synthesized, evaluated for hypoglycemic and hyperglycemic activity various substituted-synthesized
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Beschreibung
Zusammenfassung:	2-(Substituted anilino) 4-(substituted phenyl)thiazoles were synthesized by condensing 2-haloketones with substituted thioureas. The biological screening of some compounds indicated hypoglycemic and hyperglycemic activity.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600670447