Correlation of Quinidine Absorption with Disintegration and Dissolution Rates

The dissolution profiles of four commercial quinidine sulfate tablets were determined using the USP rotating-basket dissolution apparatus. Substantial differences in dissolution half-times were noted and compared to previously reported disintegration times, absorption rate constants, and times of appearance of peak serum concentrations. Rank-order correlations were observed among all combinations of in vivo and in vitro parameters, indicating that the absorption rates of these tablets are controlled by both disintegration and dissolution.