Inhibition of macrophage migration by synthetic muramyl dipeptide

N-acetylmuramyl-L-alanyl-D-isoglutamine, a synthetic compound which is known to have a minimal effective structure for an adjuvant activity of cell wall peptidoglycans, was found to inhibit the migration of normal macrophages. It was shown that the inhibition was neither due to cytotoxic or agglutin...

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Veröffentlicht in:	Biochemical and biophysical research communications 1978-02, Vol.80 (4), p.923-928
Hauptverfasser:	Yamamoto, Yusei, Nagao, Shigeki, Tanaka, Atsushi, Koga, Toshitaka, Onoue, Kaoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Adhesion - drug effects Cell Aggregation - drug effects Cell Migration Inhibition Female Glycopeptides - pharmacology Guinea Pigs Lectins Macrophages - drug effects Macrophages - physiology Muramic Acids - pharmacology
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Zusammenfassung:	N-acetylmuramyl-L-alanyl-D-isoglutamine, a synthetic compound which is known to have a minimal effective structure for an adjuvant activity of cell wall peptidoglycans, was found to inhibit the migration of normal macrophages. It was shown that the inhibition was neither due to cytotoxic or agglutinating effect of the muramyl dipeptide on macrophages nor due to lymphokine production uopn stimulation of lymphocytes by the muramyl dipeptide.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(78)91333-5