The Influence of Anaerobiosis on Human Erythrocyte Metabolism

The Influence of Anaerobiosis on Human Erythrocyte Metabolism

Summary Anaerobiosis caused a small increase in lactate production when oxygenated and deoxygenated human erythro-cytes had similar initial and final pH values. This change could be attributed to PFK activation. Under physiological conditions, PK also appeared to be activated, as judged by the marke...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1977-03, Vol.154 (3), p.356-359
Hauptverfasser: Marshall, Wayne E., Goldinger, James M., Omachi, Akira
Format: Artikel
Sprache:eng
Schlagworte:
Adenine Nucleotides - metabolism
Anaerobiosis
Erythrocytes - metabolism
Glycolysis
Hemoglobins - metabolism
Humans
Hydrogen-Ion Concentration
Lactates - biosynthesis
Male
Metabolism
Oxygen - blood
Phosphofructokinase-1 - metabolism
Pyruvate Kinase - metabolism
Pyruvates - metabolism
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Zusammenfassung:Summary Anaerobiosis caused a small increase in lactate production when oxygenated and deoxygenated human erythro-cytes had similar initial and final pH values. This change could be attributed to PFK activation. Under physiological conditions, PK also appeared to be activated, as judged by the marked decrease in 3-PGA concentration. When the pH rise associated with deoxygenation was allowed to take place, a threefold greater increase in lactate production was observed.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-154-39670