Inhibition of fatty acid synthesis by RMI 14,514 (5-tetradecyloxy-2-furoic acid)

RMI 14,514 strongly inhibited the incorporation of label from [1- 14C]acetyl-CoA into fatty acids by rat liver homogenates. No inhibition was observed when [2- 14C]malonyl-CoA was used as the labeled fatty acid precursor. These results suggest that the drug inhibits de novo fatty acid biosynthesis a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 1978-02, Vol.80 (4), p.1022-1024
Hauptverfasser:	Kariya, T., Wille, L.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl Coenzyme A - metabolism Animals Carboxylic Acids - pharmacology Fatty Acids - biosynthesis Furans - pharmacology Kinetics Liver - drug effects Liver - metabolism Male Malonyl Coenzyme A - metabolism Rats
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	RMI 14,514 strongly inhibited the incorporation of label from [1- 14C]acetyl-CoA into fatty acids by rat liver homogenates. No inhibition was observed when [2- 14C]malonyl-CoA was used as the labeled fatty acid precursor. These results suggest that the drug inhibits de novo fatty acid biosynthesis at the step mediated by acetyl-CoA carboxylase. The data presented in this communication support earlier reports that RMI 14,514 probablyexerts its hypolipidemic effects by inhibition of fatty acid biosynthesis.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(78)91347-5