THE EFFECT OF DOXAPRAM ON FETAL BREATHING IN THE SHEEP

THE EFFECT OF DOXAPRAM ON FETAL BREATHING IN THE SHEEP

Summary In five ewes of 105 to 120 days gestation intravenous doxapram (1·8 to 3·85 mg/kg) administered to the mother produced a dose‐related increase in fetal breathing. This effect of doxapram might prove useful as a test of human fetal health. Fetal breathing movements could be a sensitive indica...

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Veröffentlicht in:BJOG : an international journal of obstetrics and gynaecology 1977-01, Vol.84 (1), p.48-50
Hauptverfasser: Hogg, M. I. J., Golding, R. H., Rosen, M.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Dose-Response Relationship, Drug
Doxapram - pharmacology
Female
Fetus - drug effects
Pregnancy
Respiration - drug effects
Sheep
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Zusammenfassung:Summary In five ewes of 105 to 120 days gestation intravenous doxapram (1·8 to 3·85 mg/kg) administered to the mother produced a dose‐related increase in fetal breathing. This effect of doxapram might prove useful as a test of human fetal health. Fetal breathing movements could be a sensitive indication of the effects of drugs on the human fetal respiratory system.
ISSN:1470-0328
0306-5456
1471-0528
DOI:10.1111/j.1471-0528.1977.tb12466.x