A NEW AMINOGLYCOSIDE ANTIBIOTIC COMPLEX-THE SELDOMYCINS: III. THE STRUCTURES OF SELDOMYCIN FACTORS 1 AND 2

A NEW AMINOGLYCOSIDE ANTIBIOTIC COMPLEX-THE SELDOMYCINS: III. THE STRUCTURES OF SELDOMYCIN FACTORS 1 AND 2

The structures of seldomycin factors 1 and 2 have been determined by consideration of chemical degradation and spectral properties. Factor 1, also known as XK-88-1, is shown to be 6-0-(2-amino-2-deoxy-α-D-xylopyranosyl) paromamine (1) and factor 2, also known as XK-88-2, is shown to be 4'-deoxy...

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Veröffentlicht in:Journal of antibiotics 1977, Vol.30(1), pp.31-38
Hauptverfasser: EGAN, RICHARD S., SINCLAIR, ARTHUR C., VAULT, R. LARRY DE, MCALPINE, JAMES B., MUELLER, SANDRA L., GOODLEY, PAUL C., STANASZEK, RUTH S., CIROVIC, MOMIR, MAURITZ, ROBERT J., MITSCHER, LESTER A., SHIRAHATA, KUNIKATSU, SATO, SEIJI, IIDA, TAKAO
Format: Artikel
Sprache:eng
Schlagworte:
Amino Sugars - isolation & purification
Aminoglycosides
Anti-Bacterial Agents
Chemical Phenomena
Chemistry
Hydrolysis
Mass Spectrometry
Methods
Molecular Conformation
Oxidation-Reduction
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Zusammenfassung:The structures of seldomycin factors 1 and 2 have been determined by consideration of chemical degradation and spectral properties. Factor 1, also known as XK-88-1, is shown to be 6-0-(2-amino-2-deoxy-α-D-xylopyranosyl) paromamine (1) and factor 2, also known as XK-88-2, is shown to be 4'-deoxy-neamine (2GS). Mass spectral evidence has been obtained that suggests the most probable structure for seldomycin factor 3, also known as XK-88-3, is 6'-amino-6'-deoxyseldomycin factor 1 (12).
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.30.31