Avian muscular dystrophy: functional and biochemical improvement with diphenylhydantoin

Avian muscular dystrophy: functional and biochemical improvement with diphenylhydantoin

Chicks affected with hereditary muscular dystrophy were injected twice daily with 20 milligrams of diphenylhydantoin per kilogram of body weight on days 1 to 40 after hatching. The righting ability of dystrophic chicks treated with diphenyl-hydantoin was improved compared to that of untreated dystro...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1977-03, Vol.195 (4281), p.873-875
Hauptverfasser: Entrikin, R.K, Swanson, K.L, Weidoff, P.M, Patterson, G.T, Wilson, B.W
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcholinesterase - metabolism
animal diseases
animal health
Animals
Biochemistry
Chickens
Chicks
Dosage
Exhaustion
Hatching
L-Lactate Dehydrogenase - metabolism
Muscles
Muscles - enzymology
Muscular dystrophies
Muscular Dystrophy, Animal - drug therapy
Muscular Dystrophy, Animal - enzymology
noninfectious diseases
Normal lines
Pain
Phenytoin - therapeutic use
Physical Exertion
Poultry Diseases - drug therapy
Space life sciences
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Zusammenfassung:Chicks affected with hereditary muscular dystrophy were injected twice daily with 20 milligrams of diphenylhydantoin per kilogram of body weight on days 1 to 40 after hatching. The righting ability of dystrophic chicks treated with diphenyl-hydantoin was improved compared to that of untreated dystrophic chicks, and acetylcholinesterase activity was reduced to normal levels in the posterior latissimus dorsi muscles.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.841310