THE e ANTIGEN AND VERTICAL TRANSMISSION OF HEPATITIS B SURFACE ANTIGEN

THE e ANTIGEN AND VERTICAL TRANSMISSION OF HEPATITIS B SURFACE ANTIGEN

The relationship of e antigen (eAg) and its antibody (anti-e) to vertical transmission of hepatitis B surface antigen (HBsAg) from chronic asymptomatic HBsAg carrier women to their children was investigated in Taiwan. Sera from 20 of the 62 women studied were positive for eAg (32%); serum from only...

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Veröffentlicht in:American journal of epidemiology 1977-02, Vol.105 (2), p.94-98
Hauptverfasser: BEASLEY, R. PALMER, TREPO, CHRISTIAN, STEVENS, CLADD E., SZMUNESS, WOLF
Format: Artikel
Sprache:eng
Schlagworte:
Aspartate Aminotransferases - blood
Carrier State
Female
Hepatitis B - transmission
hepatitis B antigen
Hepatitis B Antigens - analysis
Hepatitis B Surface Antigens - analysis
Humans
Infant, Newborn
Pregnancy
Taiwan
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Zusammenfassung:The relationship of e antigen (eAg) and its antibody (anti-e) to vertical transmission of hepatitis B surface antigen (HBsAg) from chronic asymptomatic HBsAg carrier women to their children was investigated in Taiwan. Sera from 20 of the 62 women studied were positive for eAg (32%); serum from only one woman was positive for anti-e (2%). A total of 85% of the babies born to eAg positive mothers became HB5Ag carriers, while only 31% of the babies became carriers when the mother was eAg negative. Maternal a antigenemia correlated with a high HB5Ag titer, and both parameters were equally good predictors of vertical transmission.
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a112370