Cell cycle-dependent inhibition of kirsten murine sarcoma-leukemia virus release by cytochalasin B

Inhibition of Kirsten murine sarcoma-leukemia virus [KiMSV(KiMuLV)l release from chronically infected normal rat kidney cells (NRK-K) by cytochalasin B (CB) was dose dependent. Concentrations of CB between 10–25 μg/ml inhibited virus release without inhibiting mitosis and cell division. Maximal inhi...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 1977, Vol.76 (1), p.146-151
1. Verfasser:	Panem, Sandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Division - drug effects Cell Line Cytochalasin B - pharmacology Dose-Response Relationship, Drug Gammaretrovirus - drug effects Gammaretrovirus - enzymology Gammaretrovirus - growth & development Mitosis - drug effects RNA-Directed DNA Polymerase - metabolism Vinblastine - pharmacology
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Beschreibung
Zusammenfassung:	Inhibition of Kirsten murine sarcoma-leukemia virus [KiMSV(KiMuLV)l release from chronically infected normal rat kidney cells (NRK-K) by cytochalasin B (CB) was dose dependent. Concentrations of CB between 10–25 μg/ml inhibited virus release without inhibiting mitosis and cell division. Maximal inhibition occurred within 4.5 hr of adding CB to logarithmically growing NRK-K cells, and inhibition was reversed within 3 hr of drug removal. CB inhibition of virus release from synchronously growing NRK-K cells was cell-cycle dependent and occurred during late G2 phase and mitosis.
ISSN:	0042-6822 1096-0341
DOI:	10.1016/0042-6822(77)90291-4