Slow Persistent Infection Caused by Visna Virus: Role of Host Restriction

Proviral DNA has been demonstrated by in situ hybridization in foci of cells of a lamb infected with the RNA slow virus visna. A few of these cells also contain the major virion structural antigen p30. This restriction in virus gene expression in the infected animal provides a mechanism for persiste...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1977-01, Vol.195 (4274), p.175-177
Hauptverfasser:	Haase, Ashley T., Stowring, Linda, Narayan, Opendra, Griffin, Dianne, Price, Donald
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell nucleus Cell Nucleus - microbiology Cellular immunity Choroid Plexus - microbiology Culture Techniques DNA DNA probes DNA, Viral - analysis In situ hybridization Infections RNA RNA Viruses - growth & development Sheep Viral DNA Viral Proteins - analysis Virus Replication Viruses Visna maedi virus Visna-maedi virus - analysis Visna-maedi virus - growth & development
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Beschreibung
Zusammenfassung:	Proviral DNA has been demonstrated by in situ hybridization in foci of cells of a lamb infected with the RNA slow virus visna. A few of these cells also contain the major virion structural antigen p30. This restriction in virus gene expression in the infected animal provides a mechanism for persistence of virus in this chronic infection.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.188133