Immunity to Antigens Associated with Primate C-Type Oncoviruses in Pregnant Women

Cell-mediated and humoral immune responses against antigens associated with primate C-type oncoviruses were evaluated in humans by microcytotoxicity and radioimmunoprecipitation assays. Five of six women tested sequentially during pregnancy developed selective cell-mediated reactivity against baboon...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1978-03, Vol.199 (4335), p.1337-1340
Hauptverfasser: Hirsch, Martin S., Kelly, Ann P., Chapin, David S., Fuller, Thomas C., Black, Paul H., Kurth, Reinhard
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Sprache:eng
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Zusammenfassung:Cell-mediated and humoral immune responses against antigens associated with primate C-type oncoviruses were evaluated in humans by microcytotoxicity and radioimmunoprecipitation assays. Five of six women tested sequentially during pregnancy developed selective cell-mediated reactivity against baboon endogenous virus (BEV)-infected human fibroblasts. Responsiveness peaked during the second and third trimesters and corresponded temporally with elevated antibody levels to BEV antigens. Similar cell-mediated reactivity was not observed in nonpregnant individuals. Selective cell-mediated reactivity directed against cells infected with the simian sarcoma virus-simian sarcoma associated virus complex (SSV-SSAV) was observed in four of 20 healthy adults (three of 14 nonpregnant, one of six pregnant). These observations suggest that cell-mediated reactivity against primate C-type oncoviruses is occasionally detected in healthy nonpregnant adults, but that during pregnancy both cell-mediated and humoral reactivity against BEV may become selectively expressed.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.204010