Apparent positive cooperativity of ACTH action on adrenocortical cells: The effect of hormone degradation

The ability of adrenocortical cells to degrade ACTH 1–39 and [ 125I]ACTH has been assessed under various conditions. Under conditions leading to increased hormone degradation there was an elevation of both the ED 50 and the value of the Hill coefficient derived from concentration-effect curves for A...

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Veröffentlicht in:	Molecular and cellular endocrinology 1977, Vol.6 (3), p.211-216
Hauptverfasser:	Cooper, Dermot M.F., Schulster, Dennis
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTH adrenal Adrenal Cortex - drug effects Adrenal Cortex - metabolism Adrenal Cortex Hormones - biosynthesis Adrenal Glands - metabolism Adrenocorticotropic Hormone - metabolism Adrenocorticotropic Hormone - pharmacology Animals degradation In Vitro Techniques Kinetics positive cooperativity Rats
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