Apparent positive cooperativity of ACTH action on adrenocortical cells: The effect of hormone degradation

The ability of adrenocortical cells to degrade ACTH 1–39 and [ 125I]ACTH has been assessed under various conditions. Under conditions leading to increased hormone degradation there was an elevation of both the ED 50 and the value of the Hill coefficient derived from concentration-effect curves for A...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular and cellular endocrinology 1977, Vol.6 (3), p.211-216
Hauptverfasser:	Cooper, Dermot M.F., Schulster, Dennis
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTH adrenal Adrenal Cortex - drug effects Adrenal Cortex - metabolism Adrenal Cortex Hormones - biosynthesis Adrenal Glands - metabolism Adrenocorticotropic Hormone - metabolism Adrenocorticotropic Hormone - pharmacology Animals degradation In Vitro Techniques Kinetics positive cooperativity Rats
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The ability of adrenocortical cells to degrade ACTH 1–39 and [ 125I]ACTH has been assessed under various conditions. Under conditions leading to increased hormone degradation there was an elevation of both the ED 50 and the value of the Hill coefficient derived from concentration-effect curves for ACTH-stimulated steroidogenesis. Such degradative mechanisms offer a simple explanation for the apparent positive cooperativity proposed by others for ACTH-receptor-adenylate cyclase interactions.
ISSN:	0303-7207 1872-8057
DOI:	10.1016/0303-7207(77)90087-9