Influenza immunization in immunosuppressed children

Optimal influenza immunization of individuals with malignancy and other immunodeficient states requires an understanding of responses to currently recommended regimens. Children with acute lymphocytic leukemia and other malignancies between three and 17 years of age were immunized with bivalent infl...

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Veröffentlicht in:	The Journal of pediatrics 1978, Vol.92 (1), p.30-35
Hauptverfasser:	Gross, Peter A., Lee, Hahng, Wolff, James A., Hall, Caroline Breese, Minnefore, Anthony B., Lazicki, Mabel E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antineoplastic Agents - therapeutic use Child Child, Preschool Hemagglutination Inhibition Tests Humans Immunity, Cellular Immunosuppression Influenza Vaccines Influenza, Human - prevention & control Leukemia, Lymphoid - drug therapy Leukemia, Lymphoid - immunology Leukocyte Count Leukocytes - immunology Vaccination
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Zusammenfassung:	Optimal influenza immunization of individuals with malignancy and other immunodeficient states requires an understanding of responses to currently recommended regimens. Children with acute lymphocytic leukemia and other malignancies between three and 17 years of age were immunized with bivalent influenza vaccine containing A/New Jersey/76 and A/Victoria/75. Following a two-dose immunization schedule, only 37% (25/68) on cancer chemotherapy seroconverted to a hemagglutination inhibition titer ≥20 for A/NJ/76; the seroconversion rate in those not on chemotherapy was 92% (68/74, P
ISSN:	0022-3476 1097-6833
DOI:	10.1016/S0022-3476(78)80065-1