Whole-body protein synthesis and breakdown rates in children before and after reconstructive surgery of the skin

The effects of minor surgery on dynamic aspects of whole-body nitrogen metabolism were explored in healthy children aged 4–15 yr. A continuous administration of 15N-glycine was used to estimate rates of whole-body protein synthesis and breakdown both before reconstructive surgery of the skin and 5 d...

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Veröffentlicht in:Metabolism, clinical and experimental clinical and experimental, 1978, Vol.27 (1), p.27-34
Hauptverfasser: Kien, Craig L., Young, Vernon R., Rohrbaugh, Dennis K., Burke, John F.
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Sprache:eng
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Zusammenfassung:The effects of minor surgery on dynamic aspects of whole-body nitrogen metabolism were explored in healthy children aged 4–15 yr. A continuous administration of 15N-glycine was used to estimate rates of whole-body protein synthesis and breakdown both before reconstructive surgery of the skin and 5 days afterward. Mean preoperative values for protein synthesis and protein breakdown were 3.9 and 3.4 g protein/kg body weight/day, respectively. Protein synthesis decreased by 15% ( p < 0.05) postoperatively, but body weight, intake of protein and calories, nitrogen balance, and protein breakdown did not differ significantly between the two periods. Protein synthetic rate correlated ( p < 0.05) with protein ( r = +0.75) and calorie ( r = +0.58) intake. These results indicate that minor surgery causes a small decrease in the rate of whole-body protein synthesis even though calorie and nitrogen balance are maintained.
ISSN:0026-0495
1532-8600
DOI:10.1016/0026-0495(78)90120-8