Application of Salivary Concentration Data to Pharmacokinetic Studies with Antipyrine
The concentrations of antipyrine in plasma and saliva were equivalent in normal volunteers and in patients with acute viral hepatitis following oral doses of antipyrine. Estimates of clearance, volume of distribution and half‐life made from either plasma or saliva samples were not statistically diff...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1977-01, Vol.66 (1), p.135-137 |
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| container_end_page | 137 |
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| container_issue | 1 |
| container_start_page | 135 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 66 |
| creator | Meffin, Peter J. Williams, Roger L. Blaschke, Terrence F. Rowland, Malcolm |
| description | The concentrations of antipyrine in plasma and saliva were equivalent in normal volunteers and in patients with acute viral hepatitis following oral doses of antipyrine. Estimates of clearance, volume of distribution and half‐life made from either plasma or saliva samples were not statistically different in these subjects. Differences in the disposition kinetics of antipyrine during the acute phase of viral hepatitis and on recovery were detected using either plasma or saliva samples. |
| doi_str_mv | 10.1002/jps.2600660140 |
| format | Article |
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Estimates of clearance, volume of distribution and half‐life made from either plasma or saliva samples were not statistically different in these subjects. Differences in the disposition kinetics of antipyrine during the acute phase of viral hepatitis and on recovery were detected using either plasma or saliva samples.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600660140</identifier><identifier>PMID: 833730</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Acute Disease ; Analgesics-antipyrine ; Analgesics—antipyrine, pharmacokinetics, normal subjects and hepatitis patients, plasma and saliva concentration data ; Antipyrine - blood ; Antipyrine - metabolism ; Antipyrine-pharmacokinetics ; Antipyrine—pharmacokinetics, normal subjects and hepatitis patients, plasma and saliva concentration data ; Hepatitis, Viral, Human - metabolism ; Humans ; Kinetics ; Male ; normal subjects and hepatitis patients ; pharmacokinetics ; Pharmacokinetics-antipyrine ; Pharmacokinetics—antipyrine, normal subjects and hepatitis patients, plasma and saliva concentration data ; plasma and saliva concentration data ; Saliva - metabolism</subject><ispartof>Journal of pharmaceutical sciences, 1977-01, Vol.66 (1), p.135-137</ispartof><rights>1977 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1977 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4260-cc674596c41c2890552eef70580a296fb5321bbe9ad21e73e509c14182cb571f3</citedby><cites>FETCH-LOGICAL-c4260-cc674596c41c2890552eef70580a296fb5321bbe9ad21e73e509c14182cb571f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600660140$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600660140$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/833730$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meffin, Peter J.</creatorcontrib><creatorcontrib>Williams, Roger L.</creatorcontrib><creatorcontrib>Blaschke, Terrence F.</creatorcontrib><creatorcontrib>Rowland, Malcolm</creatorcontrib><title>Application of Salivary Concentration Data to Pharmacokinetic Studies with Antipyrine</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>The concentrations of antipyrine in plasma and saliva were equivalent in normal volunteers and in patients with acute viral hepatitis following oral doses of antipyrine. Estimates of clearance, volume of distribution and half‐life made from either plasma or saliva samples were not statistically different in these subjects. Differences in the disposition kinetics of antipyrine during the acute phase of viral hepatitis and on recovery were detected using either plasma or saliva samples.</description><subject>Acute Disease</subject><subject>Analgesics-antipyrine</subject><subject>Analgesics—antipyrine, pharmacokinetics, normal subjects and hepatitis patients, plasma and saliva concentration data</subject><subject>Antipyrine - blood</subject><subject>Antipyrine - metabolism</subject><subject>Antipyrine-pharmacokinetics</subject><subject>Antipyrine—pharmacokinetics, normal subjects and hepatitis patients, plasma and saliva concentration data</subject><subject>Hepatitis, Viral, Human - metabolism</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Male</subject><subject>normal subjects and hepatitis patients</subject><subject>pharmacokinetics</subject><subject>Pharmacokinetics-antipyrine</subject><subject>Pharmacokinetics—antipyrine, normal subjects and hepatitis patients, plasma and saliva concentration data</subject><subject>plasma and saliva concentration data</subject><subject>Saliva - metabolism</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1P3DAQxa0KCgvlyolDTr1l8Uccx8dlKbQIwUpb4Gg5zkQYsnGwvdD97-sqCMSh4mRZ7_eeZt4gdEjwlGBMjx-GMKUlxmWJSYG_oAnhFOfpI7bQJAE0Z7yQu2gvhAecMMz5DvpaMSYYnqCb2TB01uhoXZ-5Nlvqzj5rv8nmrjfQRz8qpzrqLLpsca_9Shv3aHuI1mTLuG4shOzFxvts1kc7bHySvqHtVncBDl7ffXRz9uP3_Gd-eX3-az67zE2RRs6NKUXBZWkKYmgl02QUoBWYV1hTWbY1Z5TUNUjdUAKCAcfSkIJU1NRckJbto-9j7uDd0xpCVCsbDHSd7sGtg6qYkAmUCZyOoPEuBA-tGrxdpT0VwepfjSrVqN5rTIaj1-R1vYLmDR97S7Ic5RfbweaTMHWxWH6IzkevDRH-vHm1f1SlYIKru6tztbi44ie3Z7fqJPHVyENq8tmCV8FYSNdprAcTVePs_7b4C59eoEE</recordid><startdate>197701</startdate><enddate>197701</enddate><creator>Meffin, Peter J.</creator><creator>Williams, Roger L.</creator><creator>Blaschke, Terrence F.</creator><creator>Rowland, Malcolm</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197701</creationdate><title>Application of Salivary Concentration Data to Pharmacokinetic Studies with Antipyrine</title><author>Meffin, Peter J. ; Williams, Roger L. ; Blaschke, Terrence F. ; Rowland, Malcolm</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4260-cc674596c41c2890552eef70580a296fb5321bbe9ad21e73e509c14182cb571f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Acute Disease</topic><topic>Analgesics-antipyrine</topic><topic>Analgesics—antipyrine, pharmacokinetics, normal subjects and hepatitis patients, plasma and saliva concentration data</topic><topic>Antipyrine - blood</topic><topic>Antipyrine - metabolism</topic><topic>Antipyrine-pharmacokinetics</topic><topic>Antipyrine—pharmacokinetics, normal subjects and hepatitis patients, plasma and saliva concentration data</topic><topic>Hepatitis, Viral, Human - metabolism</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Male</topic><topic>normal subjects and hepatitis patients</topic><topic>pharmacokinetics</topic><topic>Pharmacokinetics-antipyrine</topic><topic>Pharmacokinetics—antipyrine, normal subjects and hepatitis patients, plasma and saliva concentration data</topic><topic>plasma and saliva concentration data</topic><topic>Saliva - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meffin, Peter J.</creatorcontrib><creatorcontrib>Williams, Roger L.</creatorcontrib><creatorcontrib>Blaschke, Terrence F.</creatorcontrib><creatorcontrib>Rowland, Malcolm</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meffin, Peter J.</au><au>Williams, Roger L.</au><au>Blaschke, Terrence F.</au><au>Rowland, Malcolm</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application of Salivary Concentration Data to Pharmacokinetic Studies with Antipyrine</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1977-01</date><risdate>1977</risdate><volume>66</volume><issue>1</issue><spage>135</spage><epage>137</epage><pages>135-137</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>The concentrations of antipyrine in plasma and saliva were equivalent in normal volunteers and in patients with acute viral hepatitis following oral doses of antipyrine. Estimates of clearance, volume of distribution and half‐life made from either plasma or saliva samples were not statistically different in these subjects. Differences in the disposition kinetics of antipyrine during the acute phase of viral hepatitis and on recovery were detected using either plasma or saliva samples.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>833730</pmid><doi>10.1002/jps.2600660140</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1977-01, Vol.66 (1), p.135-137 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83795719 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Acute Disease Analgesics-antipyrine Analgesics—antipyrine, pharmacokinetics, normal subjects and hepatitis patients, plasma and saliva concentration data Antipyrine - blood Antipyrine - metabolism Antipyrine-pharmacokinetics Antipyrine—pharmacokinetics, normal subjects and hepatitis patients, plasma and saliva concentration data Hepatitis, Viral, Human - metabolism Humans Kinetics Male normal subjects and hepatitis patients pharmacokinetics Pharmacokinetics-antipyrine Pharmacokinetics—antipyrine, normal subjects and hepatitis patients, plasma and saliva concentration data plasma and saliva concentration data Saliva - metabolism |
| title | Application of Salivary Concentration Data to Pharmacokinetic Studies with Antipyrine |
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