Application of Salivary Concentration Data to Pharmacokinetic Studies with Antipyrine

The concentrations of antipyrine in plasma and saliva were equivalent in normal volunteers and in patients with acute viral hepatitis following oral doses of antipyrine. Estimates of clearance, volume of distribution and half‐life made from either plasma or saliva samples were not statistically different in these subjects. Differences in the disposition kinetics of antipyrine during the acute phase of viral hepatitis and on recovery were detected using either plasma or saliva samples.