Molecular events in lymphocyte differentiation: Stimulation of nonhistone nuclear protein synthesis in rabbit peripheral blood lymphocytes by anti-immunoglobulin
Using a sensitive double-labelling technique, changes in protein synthesis were investigated in rabbit peripheral blood lymphocytes at early times following stimulation with heterologous anti-immunoglobulin serum (GARG) or concanavalin A (Con A). At four hours following stimulation with either GARG...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1977-01, Vol.74 (2), p.584-591 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Decker, Janet M. Marchalonis, J.J. |
| description | Using a sensitive double-labelling technique, changes in protein synthesis were investigated in rabbit peripheral blood lymphocytes at early times following stimulation with heterologous anti-immunoglobulin serum (GARG) or concanavalin A (Con A). At four hours following stimulation with either GARG or Con A, a striking increase in the synthesis of a nonhistone nuclear protein of apparent molecular weight 30–40,000 was observed. These results suggest that lymphocyte activation by both anti-immunoglobulin and Con A includes as an early event synthesis of a nonhistone nuclear protein. |
| doi_str_mv | 10.1016/0006-291X(77)90343-6 |
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At four hours following stimulation with either GARG or Con A, a striking increase in the synthesis of a nonhistone nuclear protein of apparent molecular weight 30–40,000 was observed. These results suggest that lymphocyte activation by both anti-immunoglobulin and Con A includes as an early event synthesis of a nonhistone nuclear protein.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291X(77)90343-6</identifier><identifier>PMID: 836311</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Antigens ; Cell Nucleus - metabolism ; Chromosomal Proteins, Non-Histone - biosynthesis ; Chromosomal Proteins, Non-Histone - immunology ; Electrophoresis, Polyacrylamide Gel ; Goats - immunology ; Lymphocyte Activation ; Lymphocytes - physiology ; Molecular Weight ; Protein Biosynthesis ; Rabbits</subject><ispartof>Biochemical and biophysical research communications, 1977-01, Vol.74 (2), p.584-591</ispartof><rights>1977</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-3ec2ce81ab0a778765792748e54b5c9919f516306c0bf79840fed286ccf81bb3</citedby><cites>FETCH-LOGICAL-c356t-3ec2ce81ab0a778765792748e54b5c9919f516306c0bf79840fed286ccf81bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-291X(77)90343-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/836311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Decker, Janet M.</creatorcontrib><creatorcontrib>Marchalonis, J.J.</creatorcontrib><title>Molecular events in lymphocyte differentiation: Stimulation of nonhistone nuclear protein synthesis in rabbit peripheral blood lymphocytes by anti-immunoglobulin</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Using a sensitive double-labelling technique, changes in protein synthesis were investigated in rabbit peripheral blood lymphocytes at early times following stimulation with heterologous anti-immunoglobulin serum (GARG) or concanavalin A (Con A). At four hours following stimulation with either GARG or Con A, a striking increase in the synthesis of a nonhistone nuclear protein of apparent molecular weight 30–40,000 was observed. These results suggest that lymphocyte activation by both anti-immunoglobulin and Con A includes as an early event synthesis of a nonhistone nuclear protein.</description><subject>Animals</subject><subject>Antigens</subject><subject>Cell Nucleus - metabolism</subject><subject>Chromosomal Proteins, Non-Histone - biosynthesis</subject><subject>Chromosomal Proteins, Non-Histone - immunology</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Goats - immunology</subject><subject>Lymphocyte Activation</subject><subject>Lymphocytes - physiology</subject><subject>Molecular Weight</subject><subject>Protein Biosynthesis</subject><subject>Rabbits</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQhS3E36XwBl14hWARsOPEdlhUQhV_UhELumBn2c6Ea-TYwXYq5XF4U5zeqmLFajQ6Z76x5yB0TskbSih_SwjhTTvQH6-EeD0Q1rGGP0AHSgbStJR0D9Hh3vIUPcv5FyGUdnx4gh5LxhmlB_Tna_RgV68ThhsIJWMXsN_m5RjtVgCPbpogVcHp4mJ4h78XN1f73uA44RDD0eUSA-CwWg-Vs6RYoFLyFsoRsrtFJm2MK3iB5JYjJO2x8TGO_6zK2GxY10WNm-c1xJ8-mtW78Bw9mrTP8OKunqHrjx-uLz83V98-fbl8f9VY1vPSMLCtBUm1IVoIKXgvhlZ0EvrO9HYY6DD1lDPCLTGTGGRHJhhbya2dJDWGnaGXJ2x9_u8VclGzyxa81wHimpVkQu7MauxORptizgkmtSQ367QpStSei9qPrvajKyHUbS6K17HzO_5qZhjvh05BVPniJEP94o2DpLJ1ECyMLoEtaozu__y_P2WiZg</recordid><startdate>19770124</startdate><enddate>19770124</enddate><creator>Decker, Janet M.</creator><creator>Marchalonis, J.J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19770124</creationdate><title>Molecular events in lymphocyte differentiation: Stimulation of nonhistone nuclear protein synthesis in rabbit peripheral blood lymphocytes by anti-immunoglobulin</title><author>Decker, Janet M. ; Marchalonis, J.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-3ec2ce81ab0a778765792748e54b5c9919f516306c0bf79840fed286ccf81bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Cell Nucleus - metabolism</topic><topic>Chromosomal Proteins, Non-Histone - biosynthesis</topic><topic>Chromosomal Proteins, Non-Histone - immunology</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Goats - immunology</topic><topic>Lymphocyte Activation</topic><topic>Lymphocytes - physiology</topic><topic>Molecular Weight</topic><topic>Protein Biosynthesis</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Decker, Janet M.</creatorcontrib><creatorcontrib>Marchalonis, J.J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Decker, Janet M.</au><au>Marchalonis, J.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular events in lymphocyte differentiation: Stimulation of nonhistone nuclear protein synthesis in rabbit peripheral blood lymphocytes by anti-immunoglobulin</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1977-01-24</date><risdate>1977</risdate><volume>74</volume><issue>2</issue><spage>584</spage><epage>591</epage><pages>584-591</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Using a sensitive double-labelling technique, changes in protein synthesis were investigated in rabbit peripheral blood lymphocytes at early times following stimulation with heterologous anti-immunoglobulin serum (GARG) or concanavalin A (Con A). At four hours following stimulation with either GARG or Con A, a striking increase in the synthesis of a nonhistone nuclear protein of apparent molecular weight 30–40,000 was observed. These results suggest that lymphocyte activation by both anti-immunoglobulin and Con A includes as an early event synthesis of a nonhistone nuclear protein.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>836311</pmid><doi>10.1016/0006-291X(77)90343-6</doi><tpages>8</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1977-01, Vol.74 (2), p.584-591 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Antigens Cell Nucleus - metabolism Chromosomal Proteins, Non-Histone - biosynthesis Chromosomal Proteins, Non-Histone - immunology Electrophoresis, Polyacrylamide Gel Goats - immunology Lymphocyte Activation Lymphocytes - physiology Molecular Weight Protein Biosynthesis Rabbits |
| title | Molecular events in lymphocyte differentiation: Stimulation of nonhistone nuclear protein synthesis in rabbit peripheral blood lymphocytes by anti-immunoglobulin |
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