HLA frequencies in primary immunodeficiency diseases (pidd)

HLA frequencies in primary immunodeficiency diseases (pidd)

Thirteen patients with primary immunodeficiency disorders and their twenty-five healthy first-degree relatives were tissue typed and their HLA make-up was compared with that of a normal control population. HLA-A2 occured in 92.3% of patients as opposed to 60.8% in the control group (P less than 0.02...

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Veröffentlicht in:European Journal of Pediatrics 1977-02, Vol.124 (3), p.199-205
Hauptverfasser: Evers, K G, Krüger, J, Hägele, R, Haase, W, Leven, B
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Child
Child, Preschool
Female
Gene Frequency
Histocompatibility Antigens
HLA Antigens
Humans
Immunologic Deficiency Syndromes - immunology
Infant
Male
Phenotype
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Beschreibung
Zusammenfassung:Thirteen patients with primary immunodeficiency disorders and their twenty-five healthy first-degree relatives were tissue typed and their HLA make-up was compared with that of a normal control population. HLA-A2 occured in 92.3% of patients as opposed to 60.8% in the control group (P less than 0.02), HLA-A9 in 7.6% vs. 25% (P less than 0.02) and HLA-B8 in 0% vs. 21% (P less than 0.04). One of the patients with severe combined immunodeficiency showed one "extraneous" HLA specifity.
ISSN:0340-6199
0340-6997
1432-1076
DOI:10.1007/BF00452111