Simultaneous High‐Pressure Liquid Chromatographic Determination of Niacin and Niacinamide in Multivitamin Preparations: Reversed‐Phase, Ion‐Pairing Approach

A high‐pressure liquid chromatographic procedure for the simultaneous determination of niacin and niacinamide in multivitamin preparations was developed and evaluated. Reversed‐phase liquid chromatography with dioctyl sodium sulfosuccinate in the mobile phase is utilized for the analysis. The accura...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1977-01, Vol.66 (1), p.40-42
Hauptverfasser:	Sood, S. Paul, Wittmer, D.P., Ismaiel, S.A., Haney, W.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, High Pressure Liquid Drug Combinations High-pressure liquid chromatography High‐pressure liquid chromatography, reversed phase—simultaneous analysis, niacin and niacinamide in multivitamin preparations Macm and niacinamide-simultaneous analysis Macm and niacinamide—simultaneous analysis, reversed‐phase high‐pressure liquid chromatography, multivitamin preparations Methods multivitamin preparations niacin and niacinamide in multivitamin preparations Niacin and niacinamide—simultaneous analysis, reversed‐phase high‐pressure liquid chromatography, multivitamin preparations Niacinamide - analysis Nicotinic Acids - analysis reversed phase-simultaneous analysis reversed-phase high-pressure liquid chromatography simultaneous analysis Vitamins - administration & dosage Vitamins-niacin and niacinamide Vitamins—niacin and niacinamide, simultaneous analysis, reversed‐phase high‐pressure liquid chromatography, multivitamin preparations
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Beschreibung
Zusammenfassung:	A high‐pressure liquid chromatographic procedure for the simultaneous determination of niacin and niacinamide in multivitamin preparations was developed and evaluated. Reversed‐phase liquid chromatography with dioctyl sodium sulfosuccinate in the mobile phase is utilized for the analysis. The accuracy and precision of the procedure were compared with those of the currently official procedure.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600660109