Synthesis and screening of some substituted 3.5-dioxopyrazolidines

Seven new 3.5-dioxopyrazolidine derivatives, incorporating in their molecule a p-substituted benzoyl grouping, were synthesized. The preliminary screening of four selected compounds showed that 1-phenyl-2-[p-nitrobenzoyl]-4.4-diethyl-3.5-dioxopyrazolidine possesses a low order of antiinflammatory ac...

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Veröffentlicht in:	Pharmazie 1976-11, Vol.31 (11), p.774-775
Hauptverfasser:	Nasr, H, El-Zanfally, S, Khalifa, M, Abu-Shady, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - chemical synthesis Drug Evaluation, Preclinical Gossypium Inflammation - chemically induced Phenylbutazone - pharmacology Pyrazoles - chemical synthesis Pyrazoles - pharmacology Rats
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Zusammenfassung:	Seven new 3.5-dioxopyrazolidine derivatives, incorporating in their molecule a p-substituted benzoyl grouping, were synthesized. The preliminary screening of four selected compounds showed that 1-phenyl-2-[p-nitrobenzoyl]-4.4-diethyl-3.5-dioxopyrazolidine possesses a low order of antiinflammatory activity.
ISSN:	0031-7144