A potent polyamine analog, spermindiol

A potent polyamine analog, spermindiol

The effects of spermine, putrescine, and spermindiol on different nucleases were investigated. A highly active spermine analog, spermindiol, was synthesized, which markedly enhanced DNA hydrolysis by staphylococcal nuclease and spleen DNase II [EC 3.1.4.6] and RNA degradation by staphylococcal nucle...

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Veröffentlicht in:Journal of biochemistry (Tokyo) 1976-10, Vol.80 (4), p.891-893
Hauptverfasser: Yanagawa, H, Ogawa, Y, Egami, F. (Mitsubishi Chemical Industries Ltd., Machida, Tokyo (Japan). Inst. of Life Sciences)
Format: Artikel
Sprache:eng
Schlagworte:
Binding Sites
Deoxyribonucleases - metabolism
DNA
Micrococcal Nuclease - metabolism
Nucleic Acid Denaturation
Ribonucleases - metabolism
RNA
Spermine - analogs & derivatives
Spermine - biosynthesis
Spermine - pharmacology
Spleen - enzymology
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Zusammenfassung:The effects of spermine, putrescine, and spermindiol on different nucleases were investigated. A highly active spermine analog, spermindiol, was synthesized, which markedly enhanced DNA hydrolysis by staphylococcal nuclease and spleen DNase II [EC 3.1.4.6] and RNA degradation by staphylococcal nuclease and pancreatic RNase A [EC 3.1.4.22]. Spermindiol also increased the melting temperature of calf thymus DNA.
ISSN:0021-924X
1756-2651
DOI:10.1093/oxfordjournals.jbchem.a131353