DETECTION OF ONCORNAVIRUS-LIKE PARTICLES IN NORMAL AND TUMORIGENIC RAT LIVER CELL CULTURES

Six epithelial cell cultures established from adult Wistar rat liver were examined by electron microscopy for oncornavirus-like particles. Two heteroploid and tumorigenic cultures demonstrated many cells with virus-like particles of type-A and type-C morphology. The remaining four, composed of diplo...

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Veröffentlicht in:	GANN Japanese Journal of Cancer Research 1976/10/31, Vol.67(5), pp.755-762
Hauptverfasser:	NARAYAN, K. Shankar, THOMPSON, Mary Ann, OKIGAKI, Tohru
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Viral - analysis Bromodeoxyuridine - pharmacology Cells, Cultured Inclusion Bodies, Viral - ultrastructure Liver - microbiology Microscopy, Electron Neoplasms, Experimental - microbiology Oncogenic Viruses - isolation & purification Oncornavirus-like particles Rat liver cell cultures Retroviridae - isolation & purification RNA Viruses - isolation & purification RNA-Directed DNA Polymerase - metabolism Type A and C particles
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Zusammenfassung:	Six epithelial cell cultures established from adult Wistar rat liver were examined by electron microscopy for oncornavirus-like particles. Two heteroploid and tumorigenic cultures demonstrated many cells with virus-like particles of type-A and type-C morphology. The remaining four, composed of diploid nontumorigenic cells, demonstrated similar virus-like particles but in fewer cells and only after bromodeoxyuridine treatment. The virus-like particles in the tumorigenic cultures were identified as a rat type-C virus by serological assays.
ISSN:	0016-450X
DOI:	10.20772/cancersci1959.67.5_755