EFFECT OF 4-HYDROXYPYRAZOLO[3, 4-d]PYRIMIDINE (ALLOPURINOL) ADMINISTRATION ON GROWTH OF EHRLICH TUMOR CELLS

Effect of the administration of 4-hydroxypyrazolo[3, 4-d]pyrimidine (allopurinol) on the growth of Ehrlich ascites tumor cells was investigated in an in vivo system. Oral administration of allopurinol (0.1% in diet) suppressed the growth of both ascites and solid types of the tumor after the implantation of Ehrlich tumor cells in mice. The inhibitory action depended on the dose but was lost repidly when the administration was interrupted. Possible mechanisms involved in the inhibitory effect of allopurinol on tumor growth were briefly discussed.