Effect of an inhibitor of pepsin proteolytic activity in the Exalto-Mann-Williamson ulcer

The role of pepsin proteolytic activity in the Exalto-Mann-Williamson ulcer has previously not been established. Our studies show that a potent inhibitor of pepsin activity, when administered orally to E-M-W dogs, reduced both the incidence and severity of jejunal ulceration. These results indicate...

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Veröffentlicht in:	European journal of pharmacology 1977-01, Vol.41 (2), p.235-237
Hauptverfasser:	Alphin, Reevis S., Droppleman, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Weight Disease Models, Animal Dogs Female Hematocrit Hemoglobinometry Inhibitor Lignin - analogs & derivatives Lignin - pharmacology Lignin - therapeutic use Male Pepsin Pepsin A - antagonists & inhibitors Pepsin A - physiology Proteins - metabolism Stomach Ulcer - blood Stomach Ulcer - enzymology Stomach Ulcer - prevention & control Ulcer
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Zusammenfassung:	The role of pepsin proteolytic activity in the Exalto-Mann-Williamson ulcer has previously not been established. Our studies show that a potent inhibitor of pepsin activity, when administered orally to E-M-W dogs, reduced both the incidence and severity of jejunal ulceration. These results indicate that pepsin may play a major role in the development of ulceration in this model.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(77)90216-3