Effect of the Site of Release on the Absorption of Trimeprazine-S35 and Penicillin G in Dogs

A radiofrequency generator described in a previous paper was applied to release trimeprazine-S35 and potassium penicillin G at selected sites in the gastrointestinal tract of dogs. Plasma and urinary excretion data indicate that trimeprazine-S35 is readily and efficiently absorbed when released in the stomach and the upper and middle small intestine. Potassium penicillin G in its biologically active form is more available for absorption when released just beyond the pylorus than when released in either the stomach or more than 3 ft. beyond the pylorus.