Some aspects of the hepatic metabolism of ethrane

Some aspects of the hepatic metabolism of ethrane

From our studies of the rat we report observations on three aspects of the interaction of ethrane and liver. 1. Interaction of ethrane with cytochrome P450 in vitro. 2. The effect of ethrane administration on glutathione levels in vivo. 3. The effects of repeated ethrane administration in the absenc...

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Veröffentlicht in:South African medical journal 1976-12, Vol.50 (52), p.2080-2082
Hauptverfasser: Harrison, G G, Marsh, J A, Bradshan, J J, Zietsman, I, Ivanetich, K M
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cytochrome P-450 Enzyme System - metabolism
Enflurane - metabolism
Enflurane - pharmacology
Glutathione - analysis
In Vitro Techniques
Liver - analysis
Liver - drug effects
Liver - metabolism
Male
Methyl Ethers - metabolism
Microsomes, Liver - enzymology
Phenobarbital - pharmacology
Rats
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Zusammenfassung:From our studies of the rat we report observations on three aspects of the interaction of ethrane and liver. 1. Interaction of ethrane with cytochrome P450 in vitro. 2. The effect of ethrane administration on glutathione levels in vivo. 3. The effects of repeated ethrane administration in the absence and presence of microsomal enzymic induction on liver morphology. We conclude that ethrane has little or no propensity for damaging the liver.
ISSN:0256-9574