Phosphodiesterase activity of normal skeletal muscle of children

Phosphodiesterase activity of normal skeletal muscle of children

Phosphodiesterase (PDE) activity of three preparations (homogenate, particulate and soluble fractions) of normal skeletal muscle of children aged 1–13 was studied. No significant differences in PDE activity were observed in respect to the age. The preparations showed similar properties to those from...

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Veröffentlicht in:Pharmacological research communications 1976-10, Vol.8 (5), p.511-518
Hauptverfasser: Furlanut, M., Benetello, P., Campioni, A.
Format: Artikel
Sprache:eng
Schlagworte:
3',5'-Cyclic-AMP Phosphodiesterases
Adolescent
Child
Child, Preschool
Egtazic Acid - pharmacology
Humans
Imidazoles - pharmacology
In Vitro Techniques
Infant
Kinetics
Muscles - enzymology
Papaverine - pharmacology
Phosphoric Diester Hydrolases - metabolism
Theophylline - pharmacology
Time Factors
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Zusammenfassung:Phosphodiesterase (PDE) activity of three preparations (homogenate, particulate and soluble fractions) of normal skeletal muscle of children aged 1–13 was studied. No significant differences in PDE activity were observed in respect to the age. The preparations showed similar properties to those from animal tissues. At least two different apparent km were demonstrated. Enzyme activity was sensitive to papaverine, theophylline and EGTA. Imidazole stimulated only the soluble preparation.
ISSN:0031-6989
1879-2936
DOI:10.1016/0031-6989(76)90061-8