Location of Renshaw Cells

EVER since their discovery 1 , the mammalian spinal cord interneurones known as ‘Renshaw cells’ 2 have been the object of extensive physiological and pharmacological research 3 . The recurrent inhibitory pathway from motor axon collaterals via Renshaw cells back to motoneurones serves as one of the best-documented examples of a negative feed-back mechanism in the central nervous system. Furthermore, the cholinergic synapses made by the motor axon collaterals on Renshaw cells are the most thoroughly analysed central synapses from the point of view of their pharmacology.