Effect of phosvitin on smooth muscle “in vitro”

Phosvitin's activity on isolated guinea-pig ileum and on normal and hypoxic rat aortic strips was studied. Under both experimental conditions, phosvitin enhanced the responses of aortic strips to norepinephrine, whereas the phosphorylated comparison compounds, phosphocreatine, phosphoserine and...

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Veröffentlicht in:	Pharmacological research communications 1976-06, Vol.8 (3), p.319-323
Hauptverfasser:	Caprino, L., Borrelli, F., Falchetti, R., Politi, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - drug effects Egg Proteins - pharmacology Guinea Pigs Ileum - drug effects In Vitro Techniques Male Muscle, Smooth - drug effects Norepinephrine - antagonists & inhibitors Phosphates - pharmacology Phosphocreatine - pharmacology Phosphorus - pharmacology Phosvitin - pharmacology Potassium - pharmacology Rats Serine - pharmacology
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Beschreibung
Zusammenfassung:	Phosvitin's activity on isolated guinea-pig ileum and on normal and hypoxic rat aortic strips was studied. Under both experimental conditions, phosvitin enhanced the responses of aortic strips to norepinephrine, whereas the phosphorylated comparison compounds, phosphocreatine, phosphoserine and KH 2PO 4, were without effect. In the isolated guinea-pig ileum test, phosvitin showed no spasmogenic or spasmolytic activity.
ISSN:	0031-6989 1879-2936
DOI:	10.1016/0031-6989(76)90021-7