Simplified 2,6-Di-tert-butyl-p-cresol Colorimetric Method for Unsaturated-3-keto Steroids

Simplified 2,6-Di-tert-butyl-p-cresol Colorimetric Method for Unsaturated-3-keto Steroids

An improved modification of the original 2,6-DTBPC method for the determination of unsaturated 3-keto steroids has been developed. The presented technique features a simpler mode of operation, improved sensitivity, equivalent reproducibility, and extension of the original method to the analyses of 6...

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Veröffentlicht in:Journal of pharmaceutical sciences 1964-09, Vol.53 (9), p.1119-1121
Hauptverfasser: Schulz, E.P., Diaz, M.A., Guerrero, L.M.
Format: Artikel
Sprache:eng
Schlagworte:
Butylated Hydroxytoluene
Chemistry, Pharmaceutical
Colorimetry
Cortisone
Cresols
Fluocinolone Acetonide
Hydrocortisone
Old Medline
Paramethasone
Steroids
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Zusammenfassung:An improved modification of the original 2,6-DTBPC method for the determination of unsaturated 3-keto steroids has been developed. The presented technique features a simpler mode of operation, improved sensitivity, equivalent reproducibility, and extension of the original method to the analyses of 6-fluoro 3-keto steroids unsaturated at both the 1 and 4 positions. Limited application to pharmaceutical dosage forms is also discussed.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600530933