Syntheses of 2-Guanidino-2-methylpropylamine Derivatives

The polyamines which were obtained by the hydrogenation of N-substituted 2-methyl-2-nitropropylamines, were derived to the corresponding guanidine derivatives with S-methylisothiourea sulfate. Some polyamines were not derived to the guanidine compound, but to the sulfates of starting materials. The...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1964/08/25, Vol.12(8), pp.946-950
Hauptverfasser: Tsuji, Tadakazu, Ueda, Takeo
Format: Artikel
Sprache:eng
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Zusammenfassung:The polyamines which were obtained by the hydrogenation of N-substituted 2-methyl-2-nitropropylamines, were derived to the corresponding guanidine derivatives with S-methylisothiourea sulfate. Some polyamines were not derived to the guanidine compound, but to the sulfates of starting materials. The material 2-methyl-2-nitropropylamines were prepared by the condensation of 2-nitropropane, formaldehyde and amines.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.12.946