Ethylation: Biological Formation of an S-Ethyl Homolog of Lincomycin

Ethylation: Biological Formation of an S-Ethyl Homolog of Lincomycin

Streptomyces umbrinus var. cyaneoniger produces the antibiotic lincomycin. When grown in the presence of ethionine an additional antibiotic is produced. Physical and chemical analyses and incorporation of radioisotopes indicate that the new antibiotic is the S-ethyl homolog of lincomycin.

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1964-12, Vol.146 (3652), p.1691-1692
Hauptverfasser: Patterson, E. L., Hash, J. H., Lincks, M., Miller, P. A., Bohonos, N.
Format: Artikel
Sprache:eng
Schlagworte:
Alcoholic beverages
Amino Acids - metabolism
Anti-Bacterial Agents
Antibiotics
Chemical bases
Ethionine
Hydrochlorides
Lincomycin
Methionine
Old Medline
Paper chromatography
Plant growth
Purines
RNA
Salts
Streptomyces
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Zusammenfassung:Streptomyces umbrinus var. cyaneoniger produces the antibiotic lincomycin. When grown in the presence of ethionine an additional antibiotic is produced. Physical and chemical analyses and incorporation of radioisotopes indicate that the new antibiotic is the S-ethyl homolog of lincomycin.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.146.3652.1691